New drugs are not enough-drug repositioning in oncology: An update
Identifieur interne : 000093 ( an2020/Analysis ); précédent : 000092; suivant : 000094New drugs are not enough-drug repositioning in oncology: An update
Auteurs : Romina Gabriela Armando ; Diego Luis Mengual G Mez ; Daniel Eduardo GomezSource :
- International Journal of Oncology [ 1019-6439 ] ; 2020.
Abstract
Drug repositioning refers to the concept of discovering novel clinical benefits of drugs that are already known for use treating other diseases. The advantages of this are that several important drug characteristics are already established (including efficacy, pharmacokinetics, pharmacodynamics and toxicity), making the process of research for a putative drug quicker and less costly. Drug repositioning in oncology has received extensive focus. The present review summarizes the most prominent examples of drug repositioning for the treatment of cancer, taking into consideration their primary use, proposed anticancer mechanisms and current development status.
Url:
DOI: 10.3892/ijo.2020.4966
PubMed: 32124955
PubMed Central: 7010222
Affiliations:
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The advantages of this are that several important drug characteristics are already established (including efficacy, pharmacokinetics, pharmacodynamics and toxicity), making the process of research for a putative drug quicker and less costly. Drug repositioning in oncology has received extensive focus. The present review summarizes the most prominent examples of drug repositioning for the treatment of cancer, taking into consideration their primary use, proposed anticancer mechanisms and current development status.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gupta, Sc" uniqKey="Gupta S">SC Gupta</name></author><author><name sortKey="Sung, B" uniqKey="Sung B">B Sung</name></author><author><name sortKey="Prasad, S" uniqKey="Prasad S">S Prasad</name></author><author><name sortKey="Webb, Lj" uniqKey="Webb L">LJ Webb</name></author><author><name sortKey="Aggarwal, Bb" uniqKey="Aggarwal B">BB Aggarwal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hanusova, V" uniqKey="Hanusova V">V Hanusova</name></author><author><name sortKey="Skalova, L" uniqKey="Skalova L">L Skalova</name></author><author><name sortKey="Kralova, V" uniqKey="Kralova V">V Kralova</name></author><author><name 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Conte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saraswati, Ap" uniqKey="Saraswati A">AP Saraswati</name></author><author><name sortKey="Relitti, N" uniqKey="Relitti N">N Relitti</name></author><author><name sortKey="Brindisi, M" uniqKey="Brindisi M">M Brindisi</name></author><author><name sortKey="Gemma, S" uniqKey="Gemma S">S Gemma</name></author><author><name sortKey="Zisterer, D" uniqKey="Zisterer D">D Zisterer</name></author><author><name sortKey="Butini, S" uniqKey="Butini S">S Butini</name></author><author><name sortKey="Campiani, G" uniqKey="Campiani G">G Campiani</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Armando, Romina Gabriela" sort="Armando, Romina Gabriela" uniqKey="Armando R" first="Romina Gabriela" last="Armando">Romina Gabriela Armando</name><name sortKey="G Mez, Diego Luis Mengual" sort="G Mez, Diego Luis Mengual" uniqKey="G Mez D" first="Diego Luis Mengual" last="G Mez">Diego Luis Mengual G Mez</name><name sortKey="Gomez, Daniel Eduardo" sort="Gomez, Daniel Eduardo" uniqKey="Gomez D" first="Daniel Eduardo" last="Gomez">Daniel Eduardo Gomez</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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